Age-related upregulation of p16 expression in mouse ovarian somatic cells correlated with reproductive function decline p16 expression and ovarian aging in mice
Yorino Sato, Yuta Kawagoe, Kazuhiro Kawamura · 2026
Read Age-related upregulation of p16 expression in mouse ovarian somatic cells correlated with reproductive function decline p16 expression and ovarian aging in mice by Yorino Sato, Yuta Kawagoe, Kazuhiro Kawamura (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0348870.txt.
Description
Yorino Sato, Yuta Kawagoe, and Kazuhiro Kawamura track a cell-aging marker called p16 in mouse ovaries as the animals grow older. The marker flags worn-out cells, and the ovary's decline drives falling fertility with age. Their 2026 study measures the marker across body tissues at four ages and checks breeding outcomes step by step.
Marker levels climbed steeply with age in ovary support cells, but not in the eggs themselves. Older females released far fewer eggs, and fewer pregnancies ended in live pups, while fertilization in the dish stayed normal. The failure point seems to come after implantation. Reading this marker in support cells could become a way to judge ovary aging without harming eggs.
Catalog record
| CREATOR | Yorino Sato, Yuta Kawagoe, Kazuhiro Kawamura |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38847 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |