WGS identifies Lynch syndrome (LS) patients and uncovers a large family with MSH2-related LS in Southern Thailand
Worrawit Wanitsuwan, Kanet Kanjanapradit, Supakool Jearanai, Yuthasak Suphasynth, Pongsatorn Supaattagorn, Sukanya Vijasika, Surasak Wanram, Chumpol Ngamphiw · 2026
Read WGS identifies Lynch syndrome (LS) patients and uncovers a large family with MSH2-related LS in Southern Thailand by Worrawit Wanitsuwan, Kanet Kanjanapradit, Supakool Jearanai, Yuthasak Suphasynth, Pongsatorn Supaattagorn, Sukanya Vijasika, Surasak Wanram, Chumpol Ngamphiw (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0348867.txt.
Description
Worrawit Wanitsuwan and co-workers use whole-genome reading to find families in southern Thailand carrying Lynch syndrome, an inherited flaw in DNA repair that sharply raises colon cancer risk. Their 2026 study sequences patients with colon or related cancers who met clinical warning signs for the syndrome.
About one in five patients carried a suspect change in a repair gene. One change appeared in ten patients who turned out to share common ancestry. Testing their relatives found fifteen more carriers, and scope checks caught growths in some before cancer formed. The math favored genetic testing over scoping every relative blindly, and the work shows how one family's testing can protect dozens of kin.
Catalog record
| CREATOR | Worrawit Wanitsuwan, Kanet Kanjanapradit, Supakool Jearanai, Yuthasak Suphasynth, Pongsatorn Supaattagorn, Sukanya Vijasika, Surasak Wanram, Chumpol Ngamphiw |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47884 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |