HIV-1 genetic diversity and reverse transcriptase resistance mutations in Benin before dolutegravir era, West Africa
Edmond Tchiakpe, René Kpemahouton Keke, Patricia Recordon-Pinson, Abou Abdallah Malick Diouara, Marie-Line Andreola, Moussa Bachabi, Aldric Afangnihoun, Eric Gbaguidi · 2026
Read HIV-1 genetic diversity and reverse transcriptase resistance mutations in Benin before dolutegravir era, West Africa by Edmond Tchiakpe, René Kpemahouton Keke, Patricia Recordon-Pinson, Abou Abdallah Malick Diouara, Marie-Line Andreola, Moussa Bachabi, Aldric Afangnihoun, Eric Gbaguidi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0348800.txt.
Description
Edmond Tchiakpe and colleagues mapped the genetic variety of HIV and its drug resistance in Benin, using samples from patients on treatment before the country switched to the drug dolutegravir in 2019. Patients had been on therapy for at least a year. The team measured virus levels nationwide and sequenced the virus in those whose treatment was failing.
Sequencing covered the parts of the virus targeted by older drugs, letting the researchers name viral subtypes and spot resistance mutations. A pre-switch baseline like this is valuable: it shows how much resistance the old regimens left behind and which viral families circulate in Benin. That record helps judge whether the newer first-line treatment starts from a strong or shaky position.
Catalog record
| CREATOR | Edmond Tchiakpe, René Kpemahouton Keke, Patricia Recordon-Pinson, Abou Abdallah Malick Diouara, Marie-Line Andreola, Moussa Bachabi, Aldric Afangnihoun, Eric Gbaguidi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23629 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |