Response surface methodology to optimize the green synthesis process of cefotaxime sodium: Collaborative improvement of yield, crystal form control and environmental benefits
Wang Yizhang, Li Jing, Yang Mingxi, Ou Shiqiang, Liu Hao, Xie Peng, Zhu Kaimei · 2026
Read Response surface methodology to optimize the green synthesis process of cefotaxime sodium: Collaborative improvement of yield, crystal form control and environmental benefits by Wang Yizhang, Li Jing, Yang Mingxi, Ou Shiqiang, Liu Hao, Xie Peng, Zhu Kaimei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0348350.txt.
Description
Wang Yizhang and colleagues used a statistical optimisation method to green the making of cefotaxime sodium, a widely used antibiotic. Three knobs, reaction temperature, the amount of wash liquid, and the ratio of the salt-forming ingredient, were tuned together against yield, purity, and an environmental score. Single-factor trials had mapped the sensible ranges first.
The winning recipe ran cool, at a moderate wash volume and an even salt ratio. It delivered a stable, high yield with low impurities. Its crystals were clean and regular, confirmed by X-ray and microscope checks. Its green chemistry score came out excellent. The authors argue that designing for yield, crystal quality, and environmental performance in one experiment, rather than trading them off later, is how antibiotic manufacture should be modernised at factory scale.
Catalog record
| CREATOR | Wang Yizhang, Li Jing, Yang Mingxi, Ou Shiqiang, Liu Hao, Xie Peng, Zhu Kaimei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34954 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |