Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC+/- mice hearts
Anna Strnadová, Madelene Ericsson, Rakel Nyrén, Ilona Dudka, Stellan Mörner, Urban Hellman · 2026
Read Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC+/- mice hearts by Anna Strnadová, Madelene Ericsson, Rakel Nyrén, Ilona Dudka, Stellan Mörner, Urban Hellman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0342635.txt.
Description
Anna Strnadová and coauthors published a study in PLOS ONE on hypertrophic cardiomyopathy, an inherited thickening of the heart muscle that can cause heart failure and sudden death. Diseased hearts burn lots of glucose, and glucose chemistry feeds production of hyaluronan, a gel-like sugar between cells. Working with mice carrying one faulty copy of a heart protein gene, the team mapped where hyaluronan gathers and whether two beta-blockers change the picture.
Mutant hearts held far more hyaluronan than normal hearts, scattered in patches. Where the gel piled up, heart muscle cells were enlarged, tying accumulation to the thickening. A gel-making gene was switched on higher in mutants, and one beta-blocker held it at normal levels while raising a related one. Neither drug reduced the gel or the cell enlargement. The spatial link they visualized makes hyaluronan a target worth attacking directly, the authors say.
Catalog record
| CREATOR | Anna Strnadová, Madelene Ericsson, Rakel Nyrén, Ilona Dudka, Stellan Mörner, Urban Hellman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50220 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |