Association between hemoglobin glycation index and cognitive function: Evidence in the elderly
Liang Ge, Yapeng Guo, Xiangjun Xu, Junfeng Xu, Menghan Hu · 2026
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Description
Liang Ge and colleagues explored whether a blood measure called the hemoglobin glycation index tracks with thinking skills in older Americans. The index compares a person's long-term sugar marker against what their recent glucose would predict, capturing how readily someone's blood proteins soak up sugar. Data came from a national health survey of more than fourteen hundred older adults who took three standard thinking tests.
Both extremes fared worse. People with the lowest and highest index values scored below those in the middle on memory and processing speed measures, even after many adjustments. The pattern differed by sex and by whether people took diabetes medicine. The authors suggest the sweet spot sits in the middle, and that this cheap index, already computed from routine blood work, might help flag older adults at risk of decline.
Catalog record
| CREATOR | Liang Ge, Yapeng Guo, Xiangjun Xu, Junfeng Xu, Menghan Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30555 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |