A comparative study of CDO1 promoter methylation in gastric cancer and H. pylori-associated chronic gastritis: Implications for diagnostic performance
Selin Kankaya, Metehan Karatas, Engin Hatipoglu, Nuray Kepil, Zulal Kaptan, Zeynep Caliskan, Matem Tuncdemir, Yildiz Dincer · 2026
Read A comparative study of CDO1 promoter methylation in gastric cancer and H. pylori-associated chronic gastritis: Implications for diagnostic performance by Selin Kankaya, Metehan Karatas, Engin Hatipoglu, Nuray Kepil, Zulal Kaptan, Zeynep Caliskan, Matem Tuncdemir, Yildiz Dincer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0335832.txt.
Description
Selin Kankaya and co-authors compared gene silencing marks in stomach cancer and in stomach inflammation tied to a common bacterium. The tumour suppressor gene in question is often switched off by methylation, a chemical tag, during cancer development. Whether the tag appears early, in Helicobacter-related gastritis, was unclear. Their 2026 study sampled tumours, inflamed tissue with and without the bacterium, and healthy lining.
Methylation ran far higher in cancer than in uninfected gastritis or healthy tissue. Strikingly, infected gastritis matched cancer levels and exceeded uninfected gastritis. The tag separated cancer from non-cancer fairly well, but poorly from infected gastritis. Protein levels did not differ across groups. Kankaya and colleagues caution the mark alone cannot flag cancer where infection is common.
Catalog record
| CREATOR | Selin Kankaya, Metehan Karatas, Engin Hatipoglu, Nuray Kepil, Zulal Kaptan, Zeynep Caliskan, Matem Tuncdemir, Yildiz Dincer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39361 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |