ATG7 vs. ATG5: Distinct autophagy pathways shaping TGF-β signaling and endothelial function
Aman Singh, Bharatsinai Peddi, Kriti S Bhatt, Hien C Nguyen, Krishna K Singh · 2026
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Description
Aman Singh and colleagues silenced two recycling genes, ATG5 and ATG7, in blood vessel lining cells to see whether the cell's clean-up system, autophagy, treats them as interchangeable. Both genes are essential for autophagy and both interact with a major growth signal that maintains vessel health. The 2026 experiments measured gene activity and cell behaviour after each knockdown.
The two silences produced clearly different fingerprints on the growth pathway's components. Losing ATG5 made the cells multiply and migrate more vigorously, while losing ATG7 had weaker, distinct effects. The authors conclude the genes play non-redundant roles in vessel biology, a distinction that matters if autophagy is targeted to treat vascular disease.
Catalog record
| CREATOR | Aman Singh, Bharatsinai Peddi, Kriti S Bhatt, Hien C Nguyen, Krishna K Singh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41911 |
| LICENSE | CC_BY |
| RIGHTS | CC BY |
| SOURCE | PLOS |