Identification of Five Developmental Processes during Chondrogenic Differentiation of Embryonic Stem Cells
Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt · 2010
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Description
Akihiro Yamashita, Sandi Nishikawa and Derrick Rancourt published this stem cell study in PLOS ONE in 2010. Cartilage formation, chondrogenesis, is a choreographed process that later scaffolds bone, and embryonic stem cells grown in a dish replay much of that choreography. The authors used that replay to break the process into its component stages.
Stem cells differentiating toward cartilage in floating aggregates passed through five overlapping stages. First the cells condensed into clusters, then they became cartilage cells and wove a fiber scaffold, then they laid down the cartilage matrix itself, with later stages maturing the tissue. Yamashita and colleagues turn a continuous-looking transformation into a named sequence of events. A stage map helps tissue engineers check whether lab-grown cartilage is developing on schedule, a need for future joint repair material.
Catalog record
| CREATOR | Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010998