The Genome of a Bacillus Isolate Causing Anthrax in Chimpanzees Combines Chromosomal Properties of B. cereus with B. anthracis Virulence Plasmids
Silke R. Klee, Elzbieta B. Brzuszkiewicz, Herbert Nattermann et al. · 2010
Read The Genome of a Bacillus Isolate Causing Anthrax in Chimpanzees Combines Chromosomal Properties of B. cereus with B. anthracis Virulence Plasmids by Silke R. Klee, Elzbieta B. Brzuszkiewicz, Herbert Nattermann et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010986.txt.
Description
Silke Klee, Elzbieta Brzuszkiewicz, Herbert Nattermann and co-authors published this genome study in PLOS ONE in 2010. A chimpanzee in Africa died with symptoms of anthrax. Yet the bacterium isolated from it broke the rules of the anthrax species. It could move. It also lacked the usual prophages and a signature broken gene. The team sequenced its complete genome to find out what it was.
The genome held a chromosome plus three plasmids, two of which matched the anthrax virulence plasmids carrying the toxin and capsule genes. The chromosome itself resembled harmless relatives in the Bacillus cereus group. Klee and colleagues describe a hybrid threat: an ordinary-looking bacterium armed with anthrax weapons. Their finding blurs species lines used in biodefense and argues for plasmid-based detection of dangerous strains.
Catalog record
| CREATOR | Silke R. Klee, Elzbieta B. Brzuszkiewicz, Herbert Nattermann et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010986