Dissecting the Clinical Heterogeneity of Autism Spectrum Disorders through Defined Genotypes
Hilgo Bruining, Leo de Sonneville, Hanna Swaab et al. · 2010
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Description
Hilgo Bruining, Leo de Sonneville, Hanna Swaab and co-authors published this autism study in PLOS ONE in 2010. Autism spectrum disorders vary widely from person to person, and so do their genetic causes. The authors asked whether groups sharing one defined genetic cause would also share a tidier, more uniform pattern of autistic traits.
They compared the symptom profiles of autistic people with one of two genetic syndromes, a deletion on chromosome 22 or Klinefelter syndrome, against a large mixed autism sample. Standard parent-interview scores were analyzed for how alike symptoms were within each group and whether groups could be told apart. Bruining and colleagues use genetics to slice a broad diagnosis into cleaner subgroups. Such slicing could sharpen research on causes and help tailor support to each subgroup's profile.
Catalog record
| CREATOR | Hilgo Bruining, Leo de Sonneville, Hanna Swaab et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010887