Induction of Heme Oxygenase-1, Biliverdin Reductase and H-Ferritin in Lung Macrophage in Smokers with Primary Spontaneous Pneumothorax: Role of HIF-1α
Delphine Goven, Anne Boutten, Véronique Leçon-Malas et al. · 2010
Read Induction of Heme Oxygenase-1, Biliverdin Reductase and H-Ferritin in Lung Macrophage in Smokers with Primary Spontaneous Pneumothorax: Role of HIF-1α by Delphine Goven, Anne Boutten, Véronique Leçon-Malas et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010886.txt.
Description
Delphine Goven, Anne Boutten, Véronique Leçon-Malas and co-authors published this lung study in PLOS ONE in 2010. Primary spontaneous pneumothorax is a sudden lung collapse, often in young smokers, and its causes are poorly understood. The team suspected oxidative stress, damage from reactive oxygen, in the lung's resident immune cells.
They compared lung tissue from smoking and nonsmoking patients with the condition and from controls. In smokers, lung macrophages showed more of a chemical damage marker and higher levels of three protective proteins that neutralize oxidants and store iron safely. A low-oxygen control factor appeared involved in driving the response. Goven and colleagues paint the collapsed lung as a site of oxygen stress and counterattack, which may help explain why smoking raises the risk of recurrence.
Catalog record
| CREATOR | Delphine Goven, Anne Boutten, Véronique Leçon-Malas et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010886