Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy
Michelle Wehling-Henricks, Maria C. Jordan, Tomomi Gotoh et al. · 2010
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Description
Michelle Wehling-Henricks and colleagues traced how immune cells worsen scarring in muscular dystrophy, in PLOS ONE in 2010. Duchenne muscular dystrophy is a lethal inherited muscle disease that strikes young boys. Weak muscle is slowly replaced by scar tissue, in limbs and heart alike. Steroids are nearly the only treatment.
In mdx mice, the standard model, macrophages processed the amino acid arginine in a way that fed scarring. Blocking that route reduced fibrosis in muscle and heart. The immune system is thus a driver of scarring, not a bystander. A drug aimed at that route could complement future gene therapies.
Catalog record
| CREATOR | Michelle Wehling-Henricks, Maria C. Jordan, Tomomi Gotoh et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010763