Eef1a2 Promotes Cell Growth, Inhibits Apoptosis and Activates JAK/STAT and AKT Signaling in Mouse Plasmacytomas
Zhaoyang Li, Chen-Feng Qi, Dong-Mi Shin et al. · 2010
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Description
Zhaoyang Li and colleagues studied a protein that moonlights as a cancer promoter, in PLOS ONE in 2010. The protein Eef1a2 normally helps build new proteins and appears mainly in muscle, brain, and heart. It also shows up in many solid tumors, where it does not belong.
In mouse plasmacytomas, a cancer of antibody-making cells, Eef1a2 sped cell growth. It blocked programmed cell death as well. Two growth pathways, JAK/STAT and AKT, switched on under its influence. A translation helper turned growth driver is a tempting drug target, since blocking it might hit tumor cells while sparing most healthy tissue.
Catalog record
| CREATOR | Zhaoyang Li, Chen-Feng Qi, Dong-Mi Shin et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | Creative Commons CC0 License |
| RIGHTS | CC0 |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010755