Comparative Therapeutic Effects of Velaglucerase Alfa and Imiglucerase in a Gaucher Disease Mouse Model
You-Hai Xu, Ying Sun, Sonya Barnes et al. · 2010
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Description
You-Hai Xu and colleagues compared two enzyme drugs for Gaucher disease in mice, in PLOS ONE in 2010. Gaucher disease type 1 stems from a faulty lysosomal enzyme that should break down a fatty substance. Without it, the substance builds up in liver, spleen, blood, and bone. Regular infusions of a working enzyme are the standard care.
Two products, velaglucerase alfa and imiglucerase, were tested head to head. In dishes and in mice with the disease, they performed very much alike. Comparable results give doctors and patients a real choice of supplier, which matters when a lifelong drug faces shortages.
Catalog record
| CREATOR | You-Hai Xu, Ying Sun, Sonya Barnes et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010750