Loss of the Heparan Sulfate Sulfotransferase, Ndst1 , in Mammary Epithelial Cells Selectively Blocks Lobuloalveolar Development in Mice
Brett E. Crawford, Omai B. Garner, Joseph R. Bishop et al. · 2010
Read Loss of the Heparan Sulfate Sulfotransferase, Ndst1 , in Mammary Epithelial Cells Selectively Blocks Lobuloalveolar Development in Mice by Brett E. Crawford, Omai B. Garner, Joseph R. Bishop et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010691.txt.
Description
Brett Crawford and colleagues studied a sugar-chain enzyme in mouse breast tissue, in PLOS ONE in 2010. Branching ducts form many organs, and sugar chains called heparan sulfate guide that branching. The enzyme Ndst1 trims those chains in a key step.
When mammary cells lacked Ndst1, the gland's milk-making lobes failed to develop properly. Other parts of the gland formed as usual. So one trimming step controls one stage of growth, not the whole program. Stage-by-stage control like this helps explain how organs build complex shapes from simple tubes, one timed step at a time.
Catalog record
| CREATOR | Brett E. Crawford, Omai B. Garner, Joseph R. Bishop et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010691