Dengue Virus Inhibits Immune Responses in Aedes aegypti Cells
Shuzhen Sim, George Dimopoulos · 2010
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Description
Shuzhen Sim and George Dimopoulos studied how dengue virus quiets mosquito defenses, in PLOS ONE in 2010. Dengue spreads when Aedes aegypti mosquitoes bite people. The virus must first live and grow inside the mosquito, whose immune system fights back with its own gene responses.
In infected mosquito cells, many defense genes failed to switch on as they should. The virus seemed to damp the response rather than merely dodge it. That damping helps the virus build up numbers before the mosquito's next bite. Knowing which defenses get muted suggests ways to breed or engineer mosquitoes that resist dengue from within.
Catalog record
| CREATOR | Shuzhen Sim, George Dimopoulos |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010678