Reconstruction and Validation of RefRec: A Global Model for the Yeast Molecular Interaction Network
Tommi Aho, Henrikki Almusa, Jukka Matilainen et al. · 2010
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Description
Tommi Aho and colleagues rebuilt and checked a model of the yeast interaction network, in PLOS ONE in 2010. Inside a cell, thousands of proteins touch, carry, and regulate each other. Network models gather those contacts into one map that computers can analyze.
Their model, called RefRec, merged data from many experiments on yeast. The authors then validated the merged map against independent evidence. A checked map is far more useful than a pile of raw contacts. Other researchers can build on RefRec to predict what happens when a protein fails, without redoing the assembly work.
Catalog record
| CREATOR | Tommi Aho, Henrikki Almusa, Jukka Matilainen et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010662