Analysis of Gene Order Conservation in Eukaryotes Identifies Transcriptionally and Functionally Linked Genes
Marcela Dávila López, Juan José Martínez Guerra, Tore Samuelsson · 2010
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Description
Marcela Dávila López and colleagues used gene order to find linked genes, in PLOS ONE in 2010. Neighboring genes are usually shuffled apart over evolution. Pairs that stay neighbors across many species are probably kept together for a reason.
Scanning whole genomes, the team found gene pairs whose order survived across eukaryotes. Those pairs often worked in the same process and were switched on together. Order itself became a clue to function for poorly known genes. The approach turns genome maps, which labs already have, into a guide for experiments they have not yet run.
Catalog record
| CREATOR | Marcela Dávila López, Juan José Martínez Guerra, Tore Samuelsson |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010654