The Yeast PUF Protein Puf5 Has Pop2-Independent Roles in Response to DNA Replication Stress
Ana Traven, Tricia L. Lo, Trevor Lithgow et al. · 2010
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Description
Ana Traven and colleagues found a second job for a yeast RNA-binding protein, in PLOS ONE in 2010. The protein, Puf5, normally helps destroy selected messages and slow protein building. It usually works by recruiting a partner complex led by Pop2.
When DNA copying came under stress, Puf5 still protected the cells. That protection did not need the Pop2 partner at all. So Puf5 runs two separate programs, one for routine message control and one for stress. Moonlighting proteins like this complicate simple gene charts, but they also reveal backup systems cells rely on in trouble.
Catalog record
| CREATOR | Ana Traven, Tricia L. Lo, Trevor Lithgow et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010651