Investigating the Epigenetic Effects of a Prototype Smoke-Derived Carcinogen in Human Cells
Stella Tommasi, Sang-in Kim, Xueyan Zhong et al. · 2010
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Description
Stella Tommasi and colleagues examined how a smoke-related chemical rewrites cell markings, in PLOS ONE in 2010. The chemical stood in for the harmful compounds found in tobacco smoke. The team focused on methylation, the chemical tags that help control gene activity.
Human cells exposed to the compound showed widespread changes in those tags. Some regions lost tags while specific genes gained them. That double pattern matches changes seen in lung cancers linked to smoking. Mapping where the tags move helps explain how smoke can push normal cells toward cancer over time.
Catalog record
| CREATOR | Stella Tommasi, Sang-in Kim, Xueyan Zhong et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010594