In Vivo Imaging of α-Synuclein in Mouse Cortex Demonstrates Stable Expression and Differential Subcellular Compartment Mobility
Vivek K. Unni, Tamily A. Weissman, Edward Rockenstein et al. · 2010
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Description
Vivek Unni and colleagues filmed a Parkinson's-linked protein inside living mouse brains, in PLOS ONE in 2010. The protein, alpha-synuclein, builds up in the brains of people with Parkinson's disease. Earlier work relied mostly on dead tissue or cells in dishes.
Using imaging through a small window in the skull, the team tracked the protein in the cortex. Overall levels stayed steady over time. Still, the protein moved between cell compartments at different speeds. Seeing that movement in a living brain gives researchers a new way to test ideas about how the disease starts.
Catalog record
| CREATOR | Vivek K. Unni, Tamily A. Weissman, Edward Rockenstein et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010589