MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia
Jian Jiao, Lauren D. Herl, Robert V. Farese et al. · 2010
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Description
Jian Jiao and co-workers found a tiny RNA that sets the level of a brain protein tied to dementia in PLOS ONE in 2010. Too little progranulin, a brain protein, is blamed for some cases of frontotemporal dementia. That disease strikes earlier than most dementias and erodes personality and language. How progranulin levels are controlled was largely unknown. The team searched for microRNAs that bind its gene's message.
One, miR-29b, bound a site preserved across species and lowered the protein's level. A small RNA thus acts as a dimmer on a dementia-linked protein. Raising progranulin by blocking that dimmer is a conceivable therapy. The finding also explains part of the protein's normal regulation. It connects two hot fields: microRNAs and neurodegeneration.
Catalog record
| CREATOR | Jian Jiao, Lauren D. Herl, Robert V. Farese et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010551