Phospholipase D1 Mediates TNFα-Induced Inflammation in a Murine Model of TNFα-Induced Peritonitis
Swaminathan Sethu, Peter N. Pushparaj, Alirio J. Melendez · 2010
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Description
Swaminathan Sethu, Peter Pushparaj and Alirio Melendez linked an enzyme to inflammation in a mouse model of peritonitis in PLOS ONE in 2010. The signal TNF-alpha drives many inflammatory diseases. The team had shown in dishes that TNF-alpha uses an enzyme, PLD1, to switch on an inflammatory master control. They now tested that link in living mice. The model inflamed the abdominal lining, mimicking a serious human condition.
PLD1 proved necessary for the full inflammatory response in the animals. Confirming a dish result in a body is a key step toward drug development. Enzymes like PLD1 are druggable, unlike some signaling proteins. This study supports PLD1 as a target in TNF-driven diseases. It also maps one route from signal to inflammation.
Catalog record
| CREATOR | Swaminathan Sethu, Peter N. Pushparaj, Alirio J. Melendez |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010506