Chronic Effects of a Salmonella Type III Secretion Effector Protein AvrA In Vivo
Rong Lu, Shaoping Wu, Xingyin Liu et al. · 2010
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Description
Rong Lu and co-workers tracked long-term effects of a Salmonella protein inside living animals in PLOS ONE in 2010. Salmonella infection is common and can linger, raising risks of bowel disease and cancer. One bacterial protein it injects into our cells is AvrA. Evidence suggested AvrA does many jobs, from calming inflammation to altering cell growth. Most studies, though, were in dishes rather than whole animals.
Studying chronic effects in vivo shows what months of exposure do to the gut. That timescale matches the human risks under debate. If one bacterial protein nudges tissue toward disease, it becomes a target for prevention. The study extends AvrA research into realistic, long-term settings. It bridges infection biology and chronic disease research.
Catalog record
| CREATOR | Rong Lu, Shaoping Wu, Xingyin Liu et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010505