A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice
Julia Steitz, Peter G. Barlow, Jaber Hossain et al. · 2010
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Description
Julia Steitz and colleagues reported a candidate vaccine against the 2009 pandemic flu in PLOS ONE in 2010. The new H1N1 virus had spread worldwide, raising fears about vaccine supply. Their vaccine used a harmless adenovirus as a carrier for flu genes. It was built and tested in mice during the pandemic itself. Speed was of the essence, and adenovirus platforms can be made quickly.
In mice, the vaccine produced protective immunity against the pandemic strain. A carrier-based design might be stockpiled or adapted faster than egg-grown vaccines. Mouse protection does not guarantee human success, but it clears a first hurdle. The study shows pandemic vaccine science moving in near real time. It also adds evidence for adenovirus as a flu platform.
Catalog record
| CREATOR | Julia Steitz, Peter G. Barlow, Jaber Hossain et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010492