On the Control of Acute Rodent Malaria Infections by Innate Immunity
Beth F. Kochin, Andrew J. Yates, Jacobus C. de Roode et al. · 2010
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Description
Beth Kochin, Andrew Yates, Jacobus de Roode and colleagues modeled what stops early malaria in rodents for PLOS ONE in 2010. When malaria parasites first surge in the blood, something halts their rise. Three candidates compete: tailored immunity, general innate immunity, or simply running low on red blood cells to infect. Mice lacking tailored immunity show the same early pattern as normal mice. That fact already weakens the first candidate.
The authors used math models to test the remaining explanations against data. Pinpointing the brake matters for vaccines, which try to add brakes of their own. If red cell supply is the real limit, vaccine logic changes. Rodent malaria is a stand-in for the human disease, with limits. Still, the study sharpens a basic question in infection biology.
Catalog record
| CREATOR | Beth F. Kochin, Andrew J. Yates, Jacobus C. de Roode et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010444