PKMζ Inhibition Reverses Learning-Induced Increases in Hippocampal Synaptic Strength and Memory during Trace Eyeblink Conditioning
Noelia Madroñal, Agnès Gruart, Todd C. Sacktor et al. · 2010
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Description
Noelia Madroñal and co-workers tested a memory molecule in learning rats for PLOS ONE in 2010. Lasting memory is thought to need lasting strengthening of synapses in the hippocampus, a brain area vital for memory. A protein called PKMzeta is a leading candidate for holding that strength. The team trained animals in a task linking a sound to a blink response. Learning itself raised synapse strength in the hippocampus.
Blocking PKMzeta then undid both the extra strength and the memory. That reversal, after learning had finished, is the key evidence. It suggests the protein actively maintains memories rather than just forming them. A maintenance molecule could be a target in memory loss diseases. It also raises hard questions about erasing unwanted memories.
Catalog record
| CREATOR | Noelia Madroñal, Agnès Gruart, Todd C. Sacktor et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010400