Dual Function of a Bee Venom Serine Protease: Prophenoloxidase-Activating Factor in Arthropods and Fibrin(ogen)olytic Enzyme in Mammals
Young Moo Choo, Kwang Sik Lee, Hyung Joo Yoon et al. · 2010
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Description
Young Moo Choo and co-workers found a double duty enzyme in bee venom, reporting in PLOS ONE in 2010. Bee venom holds many active proteins, including a family called serine proteases. What those enzymes do for the bee was unclear. No one had described their roles in venom before this work. The team purified one and tested its actions in detail.
The enzyme did two very different jobs depending on the victim. In insects and kin, it switched on a defense pigment pathway. In mammals, it broke down fibrin, a protein in blood clots. One venom tool thus harms two kinds of animals in two ways. That economy is typical of venom evolution. It also gives drug hunters a clot-cutting enzyme to study.
Catalog record
| CREATOR | Young Moo Choo, Kwang Sik Lee, Hyung Joo Yoon et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010393