Persistent Synapse Loss Induced by Repetitive LTD in Developing Rat Hippocampal Neurons
Yo Shinoda, Tsunehiro Tanaka, Keiko Tominaga-Yoshino et al. · 2010
Read Persistent Synapse Loss Induced by Repetitive LTD in Developing Rat Hippocampal Neurons by Yo Shinoda, Tsunehiro Tanaka, Keiko Tominaga-Yoshino et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010390.txt.
Description
Yo Shinoda and colleagues watched young rat brain cells lose connections on purpose, in PLOS ONE in 2010. Growing brains first make too many synapses, the links between nerve cells. Extra or wrong links are then pruned away, sharpening the network. Healthy pruning is needed for normal development. How a link is chosen for removal was not well understood.
Repeated weak signaling, a pattern called LTD, made synapses vanish for good in their tests. That offers a mechanism: links that keep failing may be deleted. The same process, if misdirected, could matter in brain disorders. Pruning is a quiet kind of brain construction. This study helps explain how the brain edits itself as it grows.
Catalog record
| CREATOR | Yo Shinoda, Tsunehiro Tanaka, Keiko Tominaga-Yoshino et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010390