Drosophila Smad2 Opposes Mad Signaling during Wing Vein Development
Veronika Sander, Edward Eivers, Renee H. Choi et al. · 2010
Read Drosophila Smad2 Opposes Mad Signaling during Wing Vein Development by Veronika Sander, Edward Eivers, Renee H. Choi et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010383.txt.
Description
Veronika Sander and co-workers studied two competing signals in fruit fly wings for PLOS ONE in 2010. In backboned animals, two signal families often push in opposite directions during development. One family builds bone and related tissues; the other guides different fates. The balance between them shapes structures like the gastrula organizer. Flies offer a simpler place to test that rivalry.
In the fly wing, the protein Smad2 worked against the rival pathway's signal, Mad. That opposition helped pattern the veins of the wing. A fine wing pattern thus becomes a readout of signal balance. The fly work may clarify how the same balance fails in birth defects. Small wings, here, carry a general lesson about development.
Catalog record
| CREATOR | Veronika Sander, Edward Eivers, Renee H. Choi et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010383