Evidence for STAT4 as a Common Autoimmune Gene: rs7574865 Is Associated with Colonic Crohn's Disease and Early Disease Onset
Jürgen Glas, Julia Seiderer, Melinda Nagy et al. · 2010
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Description
Jürgen Glas and colleagues tested a gene called STAT4 across several immune diseases in PLOS ONE in 2010. Variants of STAT4 had already been linked to lupus and rheumatoid arthritis. That pattern hints that different autoimmune diseases share some root genes. The team asked whether the same gene also raised risk for Crohn's disease, a gut inflammation. They focused on one common variant in the gene.
That variant was tied to Crohn's affecting the colon, and to earlier onset of disease. A shared gene across lupus, arthritis, and gut disease suggests shared immune pathways. Shared pathways could mean shared treatments one day. The study adds Crohn's to the list of conditions in STAT4's reach. Genetics, here, redraws the borders between diseases.
Catalog record
| CREATOR | Jürgen Glas, Julia Seiderer, Melinda Nagy et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010373