Differential Control of Notch1 Gene Transcription by Klf4 and Sp3 Transcription Factors in Normal versus Cancer-Derived Keratinocytes
Chiara Lambertini, Serafino Pantano, G. Paolo Dotto · 2010
Read Differential Control of Notch1 Gene Transcription by Klf4 and Sp3 Transcription Factors in Normal versus Cancer-Derived Keratinocytes by Chiara Lambertini, Serafino Pantano, G. Paolo Dotto (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010369.txt.
Description
Chiara Lambertini, Serafino Pantano and G. Paolo Dotto studied control of the Notch1 gene in skin cells for PLOS ONE in 2010. In skin, Notch signals push cells to mature and can suppress tumors. When Notch1 is turned down, cancer becomes more likely. Apart from one known controller, p53, little was known about who sets its level. The team compared normal skin cells with cancer-derived ones.
Two factors, Klf4 and Sp3, handled the gene differently in the two cell types. That difference may help explain why cancer cells lose Notch1's protection. Gene control is often where cancer begins, long before visible change. Naming the controllers gives drug research new targets. It also shows the same gene can obey different masters in health and disease.
Catalog record
| CREATOR | Chiara Lambertini, Serafino Pantano, G. Paolo Dotto |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010369