Ligand Binding and Crystal Structures of the Substrate-Binding Domain of the ABC Transporter OpuA
Justina C. Wolters, Ronnie P-A. Berntsson, Nadia Gul et al. · 2010
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Description
Justina Wolters and colleagues described how a bacterial transport protein grips its cargo, in PLOS ONE in 2010. The protein system, OpuA, imports a protective compound called glycine betaine. It switches on when salt levels around the cell pass a threshold. The authors focused on the part that first grabs the cargo. They studied it both alone and as part of the purified system.
Crystal structures showed the gripping part in fine detail. Binding tests showed how tightly it holds its target. Such detail explains how bacteria survive salty or dry conditions. It may also guide designs for hardier industrial microbes. The study is a close look at one molecular hand and what it can hold. Structure, here, explains a survival trick.
Catalog record
| CREATOR | Justina C. Wolters, Ronnie P-A. Berntsson, Nadia Gul et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010361