Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway
Venkata Ramesh Dasari, Kiranpreet Kaur, Kiran Kumar Velpula et al. · 2010
Read Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway by Venkata Ramesh Dasari, Kiranpreet Kaur, Kiran Kumar Velpula et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010350.txt.
Description
Venkata Dasari and colleagues tested stem cells against glioma, a deadly brain tumor, in PLOS ONE in 2010. A gene called PTEN normally brakes a key growth pathway in cells. Most gliomas keep that pathway, known as PI3K/Akt, switched on too strongly. The brake is weak or missing, so tumor cells move and grow freely. The team used stem cells from cord blood to restore the brake.
When those stem cells met glioma cells, PTEN levels rose in the tumor cells. The overactive pathway then quieted down. As a result, the glioma cells migrated less, a step toward spreading. Stem cells here act as a delivery and repair tool, not just spare parts. The work points to a treatment idea worth testing further.
Catalog record
| CREATOR | Venkata Ramesh Dasari, Kiranpreet Kaur, Kiran Kumar Velpula et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010350