Comparison of the Immune Responses Induced by Chimeric Alphavirus-Vectored and Formalin-Inactivated Alum-Precipitated Measles Vaccines in Mice
M. Jeff Bergen, Chien-Hsiung Pan, Catherine E. Greer et al. · 2010
Read Comparison of the Immune Responses Induced by Chimeric Alphavirus-Vectored and Formalin-Inactivated Alum-Precipitated Measles Vaccines in Mice by M. Jeff Bergen, Chien-Hsiung Pan, Catherine E. Greer et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010297.txt.
Description
M Jeff Bergen and colleagues compare two measles vaccines in mice in a 2010 PLOS ONE study. Past measles vaccine failures are poorly understood, so the kind of immune response each vaccine stirs matters. Mice cannot catch measles, but their responses can still be compared side by side.
One vaccine used a weakened virus carrier bearing a measles surface protein. It drew strong, virus-killing antibodies and a balanced T cell response, the cells that direct immune attack. The other, a killed vaccine in alum, drew weak, non-killing antibodies aimed at the wrong protein, plus a skewed T cell response. Quality of response, not just amount, set the two apart.
Catalog record
| CREATOR | M. Jeff Bergen, Chien-Hsiung Pan, Catherine E. Greer et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010297