Transcriptional Analysis of the Pre-Erythrocytic Stages of the Rodent Malaria Parasite, Plasmodium yoelii
Calvin T. Williams, Abdu F. Azad · 2010
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Description
Calvin T Williams and Abdu Azad profile gene activity in the silent early stages of malaria in a 2010 PLOS ONE study. Before blood symptoms, the rodent malaria parasite passes through a mosquito-delivered spore stage and a liver stage. These stages are little studied but hold possible drug and vaccine targets.
The team compared gene activity in spores, weakened spores, and liver parasites at one and two days. Over a thousand parasite genes differed from blood stages. Weakened and normal spores looked nearly identical, as did the two liver time points. Activity grew steadily more blood-like as liver development matured. The catalog points to genes the parasite needs before illness begins.
Catalog record
| CREATOR | Calvin T. Williams, Abdu F. Azad |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010267