Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis
Tale Sliedrecht, Chao Zhang, Kevan M. Shokat et al. · 2010
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Description
The authors were Tale Sliedrecht, Chao Zhang, Kevan Shokat, and others. Their 2010 PLOS ONE study used a chemical trick to switch off a mitosis protein. Correct cell division needs chromosomes attached firmly to spindle fibers. A checkpoint delays division until every chromosome is stably attached, guarding against cells with wrong chromosome counts.
The team built stable human cell lines where the kinase Mps1 could be blocked chemically. Turning Mps1 off at chosen moments revealed new aspects of its job in mitosis. A timed off-switch gives finer answers than removing a protein for good.
Catalog record
| CREATOR | Tale Sliedrecht, Chao Zhang, Kevan M. Shokat et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010251