Paradoxical Association of C-Reactive Protein with Endothelial Function in Rheumatoid Arthritis
Michael V. Holmes, Benyu Jiang, Karen McNeill et al. · 2010
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Description
Michael V Holmes and colleagues report a surprising pattern in a 2010 PLOS ONE study of rheumatoid arthritis patients. C-reactive protein, or CRP, is a blood marker of inflammation, or swelling responses. In the general public, higher CRP tracks with worse vessel function and heart disease.
Patients with this joint disease had thicker artery walls and stiffer aortas than healthy controls, yet similar vessel widening function. Within patients, higher CRP linked to better, not worse, vessel widening, and not to wall thickness or stiffness. The authors argue CRP itself may not cause artery disease, and may even protect the vessel lining's key gas signal.
Catalog record
| CREATOR | Michael V. Holmes, Benyu Jiang, Karen McNeill et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010242