Endogenous TCR Recombination in TCR Tg Single RAG-Deficient Mice Uncovered by Robust In Vivo T Cell Activation and Selection
Caroline Montaudouin, Laurent Boucontet, Marie-Pierre Mailhé-Lembezat et al. · 2010
Read Endogenous TCR Recombination in TCR Tg Single RAG-Deficient Mice Uncovered by Robust In Vivo T Cell Activation and Selection by Caroline Montaudouin, Laurent Boucontet, Marie-Pierre Mailhé-Lembezat et al. (2010) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/plos-pone-0010238.txt.
Description
The authors were Caroline Montaudouin, Laurent Boucontet, Marie-Pierre Mailhé-Lembezat, and others. Their 2010 PLOS ONE study used special mice that are standard tools in immune research. These mice lack RAG genes and carry one fixed T cell receptor. Labs use them as a source of T cells that are all the same.
After moving those T cells into other hosts, the team found cells with new receptors. Strong activation in the body had uncovered new gene shuffling in cells thought to be fixed. That surprise warns labs that such T cell groups may not stay uniform in use.
Catalog record
| CREATOR | Caroline Montaudouin, Laurent Boucontet, Marie-Pierre Mailhé-Lembezat et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010238