Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer Pain
Zhiqian Tong, Wenhong Luo, Yanqing Wang et al. · 2010
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Description
The authors were Zhiqian Tong, Wenhong Luo, Yanqing Wang, and others. Their 2010 PLOS ONE study probed why cancers in bone hurt so much. Bone cancer pain is severe and hard to treat, and its molecular causes were under study. Blood and urine formaldehyde runs high in many cancer patients. The cancers involved, including breast and prostate tumors, often spread to bone.
The team found that formaldehyde from tumor tissue and the acidic tumor setting act together. In synergy, they induce bone cancer pain in their model. That pairing points to new targets for easing one of cancer's worst symptoms.
Catalog record
| CREATOR | Zhiqian Tong, Wenhong Luo, Yanqing Wang et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010234