Activation of the Akt Survival Pathway Contributes to TRAIL Resistance in Cancer Cells
Jing Xu, Jun-Ying Zhou, Wei-Zen Wei et al. · 2010
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Description
The authors were Jing Xu, Jun-Ying Zhou, Wei-Zen Wei, and others. Their 2010 PLOS ONE study asked why some cancer cells resist a death signal. The signal, called TRAIL, can trigger cancer cells to die by apoptosis. Many tumors resist it, and the mechanism behind that resistance was not fully understood when the team began.
The authors showed that a survival route inside cells, the Akt pathway, plays an important role. When Akt signaling is active, human cancer cells withstand TRAIL better. Blocking that survival route could make TRAIL-based treatment work on tumors that now shrug it off.
Catalog record
| CREATOR | Jing Xu, Jun-Ying Zhou, Wei-Zen Wei et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010226