Large-Scale Sequence Analysis of Hemagglutinin of Influenza A Virus Identifies Conserved Regions Suitable for Targeting an Anti-Viral Response
Leepakshi Sahini, Anna Tempczyk-Russell, Ritu Agarwal · 2010
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Description
Leepakshi Sahini, Anna Tempczyk-Russell, and Ritu Agarwal published this flu study in PLOS ONE in 2010. Hemagglutinin, the spike protein on influenza A virus, is the main target of vaccines. The problem is that the spike changes shape fast as the virus evolves. Vaccines must be remade again and again to keep up.
The team analyzed huge numbers of hemagglutinin sequences, looking for parts that stay the same. Conserved regions cannot change without hurting the virus, so they make stable targets. An antiviral aimed at such a region could work across many flu strains. Their large-scale search narrows the hunt to the most promising stretches.
Catalog record
| CREATOR | Leepakshi Sahini, Anna Tempczyk-Russell, Ritu Agarwal |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009268