Presynaptic External Calcium Signaling Involves the Calcium-Sensing Receptor in Neocortical Nerve Terminals
Wenyan Chen, Jeremy B. Bergsman, Xiaohua Wang et al. · 2010
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Description
Wenyan Chen and co-authors study calcium sensing at nerve terminals in a 2010 PLOS ONE paper. When a spike invades a nerve terminal, it opens voltage-gated channels. Calcium entry then triggers vesicle fusion and neurotransmitter release. Ion channels shape the presynaptic spike and thus regulate calcium signals. External calcium outside the terminal also carries information. The team test if the calcium-sensing receptor detects that external signal in neocortical terminals.
They find presynaptic external calcium signaling involves that receptor. The receptor lets terminals sense calcium levels around them. That sensing can adjust release strength in a feedback loop. The work adds a sensor to the standard picture of synaptic transmission.
Catalog record
| CREATOR | Wenyan Chen, Jeremy B. Bergsman, Xiaohua Wang et al. |
|---|---|
| YEAR | 2010 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008563