Caspase-2 Mediated Apoptotic and Necrotic Murine Macrophage Cell Death Induced by Rough Brucella abortus
Fang Chen, Yongqun He · 2009
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Description
Fang Chen and Yongqun He studied how a rough strain of Brucella kills mouse macrophages in PLOS ONE in 2009. Brucella bacteria live inside host cells and cause brucellosis. Surviving inside macrophages is critical for chronic infection. Smooth virulent strains block the death of their host cells. Rough strains behave differently.
The rough Brucella abortus strain induced both apoptotic and necrotic death. An enzyme called caspase-2 mediated the killing. The contrast with smooth strains highlights a survival strategy. Blocking cell death lets smooth bacteria persist quietly. Understanding the switch may expose ways to break chronic brucellosis.
Catalog record
| CREATOR | Fang Chen, Yongqun He |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006830