HIV gp120 Induces, NF-κB Dependent, HIV Replication that Requires Procaspase 8
Gary D. Bren, Sergey A. Trushin, Joe Whitman et al. · 2009
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Description
Gary Bren and colleagues studied how the HIV coat protein gp120 boosts HIV growth in PLOS ONE in 2009. The protein can switch cells on, push some cells to die, and raise output of immune signals. Through an unknown route, it also made the virus copy itself at a higher rate in the tests.
The team found that the same signals that push cells to die also drive the extra virus growth. That drive needs a cell factor called NF-kB and a protein named procaspase 8. The result links cell death paths to virus spread in a direct way. Blocking that link could one day help lower virus levels in the body.
Catalog record
| CREATOR | Gary D. Bren, Sergey A. Trushin, Joe Whitman et al. |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004875