Unusual Armadillo Fold in the Human General Vesicular Transport Factor p115
Harald Striegl, Yvette Roske, Daniel Kümmel et al. · 2009
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Description
A Golgi protein folds into an unusual armadillo shape, show Harald Striegl, Yvette Roske, Daniel Kummel, and co-authors in PLOS ONE in 2009. The protein is p115, a general vesicular transport factor. The golgin family gives identity and structure to the Golgi apparatus, the cell's shipping and sorting station, and forms part of a complex protein network at its membrane.
P115 is targeted by the GTPase Rab1a and contains a large globular head and a long coiled-coil stalk. The team solved its head's structure and found an unusual armadillo fold, a curved stack of repeating units. That shape is a scaffold for binding partners. Knowing it helps explain how the Golgi grabs incoming cargo sacs and holds its own shape.
Catalog record
| CREATOR | Harald Striegl, Yvette Roske, Daniel Kümmel et al. |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004656