Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice
Tea Gogishvili, Daniela Langenhorst, Fred Lühder et al. · 2009
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Description
Regulatory T cells rush in fast enough to stop a dangerous immune storm in mice, show Tea Gogishvili, Daniela Langenhorst, Fred Luhder, and co-authors in PLOS ONE in 2009. Superagonistic CD28 antibodies are highly effective activators of regulatory T cells in rats. But a first-in-man trial of the human version, TGN1412, caused an unexpected cytokine release syndrome that nearly killed the volunteers.
Using a new mouse antibody of the same class, the team studied what protects mice from the same storm. A rapid regulatory T cell response prevents the cytokine storm, as the title reports. Understanding that safety mechanism could let doctors use these powerful immune activators without repeating the TGN1412 disaster.
Catalog record
| CREATOR | Tea Gogishvili, Daniela Langenhorst, Fred Lühder et al. |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004643