Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
Fayçal Guedj, Catherine Sébrié, Isabelle Rivals et al. · 2009
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Description
Green tea compounds rescued mouse brains from the effects of an extra gene linked to Down syndrome, report Faycal Guedj, Catherine Sebrie, Isabelle Rivals, and co-authors in PLOS ONE in 2009. The gene is DYRK1A. People and mice carrying an extra copy of it show altered brain development. They also show learning impairments that model those seen in Down syndrome.
The team gave green tea polyphenols, plant compounds from tea, to mice with the extra gene. The treatment rescued brain defects induced by the gene's overexpression, as the title reports. Earlier brain scans and tissue studies had mapped those defects in detail. A safe dietary compound that offsets a single gene's overdose is a promising lead for Down syndrome research.
Catalog record
| CREATOR | Fayçal Guedj, Catherine Sébrié, Isabelle Rivals et al. |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004606