The HU Regulon Is Composed of Genes Responding to Anaerobiosis, Acid Stress, High Osmolarity and SOS Induction
Jacques Oberto, Sabrina Nabti, Valérie Jooste et al. · 2009
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Description
Jacques Oberto and colleagues published this bacterial genetics study in PLOS ONE in 2009. The E. coli protein HU is a small DNA-bending protein associated with the bacterial nucleoid. It can introduce negative supercoils into closed circular DNA with the help of topoisomerase I. Cells lacking HU grow very poorly and display many phenotypes, showing how central it is.
The team defined the HU regulon, the set of genes HU controls. They report it is composed of genes responding to anaerobiosis, acid stress, high osmolarity, and SOS induction. One small bending protein, it turns out, coordinates much of the bacterium's stress life.
Catalog record
| CREATOR | Jacques Oberto, Sabrina Nabti, Valérie Jooste et al. |
|---|---|
| YEAR | 2009 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PLOS ONE |
Source: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004367